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Beta-lysine 5,6-aminomutase

From Wikipedia, the free encyclopedia
beta-lysine 5,6-aminomutase
Identifiers
EC no.5.4.3.3
CAS no.9075-69-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a beta-lysine 5,6-aminomutase (EC 5.4.3.3) is an enzyme that catalyzes the chemical reaction

(3S)-3,6-diaminohexanoate (3S,5S)-3,5-diaminohexanoate

Hence, this enzyme has one substrate, (3S)-3,6-diaminohexanoate, and one product, (3S,5S)-3,5-diaminohexanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is (3S)-3,6-diaminohexanoate 5,6-aminomutase. Other names in common use include beta-lysine mutase, and L-beta-lysine 5,6-aminomutase. This enzyme participates in lysine degradation. It employs one cofactor, cobamide.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1XRS.

References

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  • Retey J, Kunz F, Arigoni D, Stadtman TC (1978). "Zur Kenntnis der beta-Lysin-Mutase-Reaktion: mechanismus und sterischer Verlauf". Helv. Chim. Acta. 61 (8): 2989–2998. doi:10.1002/hlca.19780610824.
  • Stadtman TC, Renz P (1968). "Anaerobic degradation of lysine. V. Some properties of the cobamide coenzyme-dependent beta-lysine mutase of Clostridium sticklandii". Arch. Biochem. Biophys. 125 (1): 226–39. doi:10.1016/0003-9861(68)90657-7. PMID 5649516.